Search results for "ISM [X-rays]"
showing 10 items of 1406 documents
Systemic administration of D-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats.
2010
Although recently published studies seem to confirm the important role displayed by acetaldehyde (ACH), the main metabolite of ethanol, in the behavioral effects of ethanol, the origin of ACH is still a matter of debate. While some authors confer more importance to the central (brain metabolism) origin of ACH, others indicate that the hepatic origin could be more relevant. In this study we have addressed this topic using an experimental approach that combines local microinjections of ethanol into the ventral tegmental area (VTA) (which guarantees the brain origin of the ACH) to induce motor activation in rats together with systemic administration (i.p.) of several doses (0, 12.5, 25 and 50 …
Die nächste Generation „atypischer” Antipsychotika: Der Beitrag der Positronenemissionstomographie
2003
Almost fifteen years of research with Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have led to a profound understanding of the relationships between antipsychotic doses and plasma levels on the one hand and occupancy of (striatal) D 2 -like dopamine receptors on the other hand as well as with the associated clinical effects and side effects. Furthermore, with the development of clinically atypical" antipsychotics PET studies helped to generate hypotheses regarding the essential pharmacological properties of this heterogeneous class of drugs. Possible mechanisms of action include combined D 2 -/5-HT 2 antagonism, preferential mesolimbic binding, a…
Manejo de la hiperglucemia con fármacos no insulínicos en pacientes adultos con diabetes tipo 2
2019
Resumen: El adecuado tratamiento de la diabetes mellitus tipo 2 (DM2) incluye la alimentación saludable y el ejercicio (150 min/semana) como pilares básicos. Para el tratamiento farmacológico, la metformina es el fármaco de elección inicial, salvo contraindicación o intolerancia; en caso de mal control, se dispone de 8 familias terapéuticas (6 orales y 2 inyectables) como posibles combinaciones. Se presenta un algoritmo y unas recomendaciones para el tratamiento de la DM2. En prevención secundaria cardiovascular se recomienda asociar un inhibidor del cotransportador sodio-glucosa tipo 2 (iSGLT2) o un agonista del receptor de glucagon-like peptide-1 (arGLP1) en pacientes con obesidad. En pre…
2021
The cell—cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse. Therefore, we tested for association of a functional intronic CDH13 SNP rs2199430 with ADHD in a sample of 998 adult patients and 884 healthy controls. The Big Five personality tra…
Aleksandra Zāmeļa 1925. gadā ievāktais mazā zvaguļa herbārijs
2019
Raksts par 2019. gada auga mazā zvaguļa Rhinanthus minor herbāriju, ko 1925. gada 20. jūnijā ievācis latviešu botāniķis un iedzimtības pētnieks Aleksandrs Zāmelis, un kas glabājas Latvijas Universitātes Muzeja Botānikas un mikoloģijas kolekciju Latvijas Herbārijā (Herbarium Latvicum).
Bier oder Branntwein?: Tatsachen und Erwägungen
1925
Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and …
2019
Immunomodulatory glycolipids, among which α-galactosylceramide (KRN7000) is an iconic example, have shown strong therapeutic potential in a variety of conditions ranging from cancer and infection to autoimmune or neurodegenerative diseases. A main difficulty for those channels is that they often provoke a cytokine storm comprising both pro- and anti-inflammatory mediators that antagonize each other and negatively affect the immune response. The synthesis of analogues with narrower cytokine secretion-inducing capabilities is hampered by the intrinsic difficulty at controlling the stereochemical outcome in glycosidation reactions, particularly if targeting the α-anomer, which seriously hamper…
ISLANDS TOURISM SEASONALITY
2015
The islands of the European Union, generally associated with the sun and sea, attract the great majority of tourist flows in the summer months. This characteristic is shared by all the islands, be they in the Mediterranean or in the Baltic. However, through detailed analysis and the use of specific indicators, it was demonstrated that some islands are increasingly developing winter tourism in an effort to improve the annual occupancy rate of beds and mitigate seasonality curves. This study examines some islands that are located in different seas of the European Union, at different latitudes and hence in different climatic zones. These islands are: Cyprus (CY), Sicily (IT), Madeira (PT), and…
On the topography of Herbst's and Grandry's corpuscles in the adult and embryonic duck-bill
1932
Izvilkums no: Acta Zoologica, Bd. 12, 1931.
Zur Topographie der Herbst'schen und Grandry'schen Körperchen im adulten und embryonalen Entenschnabel [Herbsta un Grandry ķermenīšu topogrāfija piea…
1931
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